Jalen Hurts won't play Sunday against the Panthers. The Eagles ruled out their quarterback because of a superficial blood clot in his calf. This is a significant blow to Philadelphia's season as they prepare for a divisional matchup. Backup Kenny Pickett figures to get the start if Hurts cannot clear league medical protocols before game day. The team will likely provide updates on his status throughout the week, but superficial clots can sideline players for multiple games depending on how the medical staff handles treatment and clearance. For fantasy owners and bettors, this changes Philadelphia's offensive outlook considerably. Hurts has been the engine of the Eagles' attack all season, and losing him to injury, even temporarily, shifts expectations for the passing game and run game alike. Pickett stepped in earlier this season with mixed results, so how the backup performs against Carolina's defense will tell us plenty about whether this becomes a one-week absence or a longer-term issue.