No. 2 Ohio State lost to unranked USC, marking the Buckeyes' first two-game loss before November since 2011. Ohio State's secondary got bullied, including a 69-yard touchdown on USC's second play. The offensive line struggled to generate push, and USC scored on four of its first six drives.
Iowa State, transformed by an offseason roster overhaul after Penn State raids, beat No. 24 Oklahoma State 51-49 on a game-winning field goal. Running back Aiden Flora rushed for 221 yards and two touchdowns, including a 75-yard breakaway score.
Nebraska lost 10-9 to Washington in the final 90 seconds. The Huskies threw a touchdown to take the lead, then Anthony Colandrea threw an interception to safety Alex McLaughlin, who returned it 48 yards for a game-sealing touchdown with 15 seconds left. The Cornhuskers have dropped three straight by a combined 13 points.
No. 4 Indiana escaped Minnesota 23-16 in overtime after kicking a 60-yard field goal in regulation's final seconds, tying the Golden Gophers' own 60-yard kick.
Wisconsin lost 30-0 to Iowa, mustering only 52 yards rushing. Iowa's Hank Brown completed 20-of-24 passes for 222 yards and two touchdowns.
Texas Tech bounced back from a loss to Cincinnati by beating No. 22 Houston and No. 22 Arizona at home with backup quarterback Thomas Castellanos, putting the Red Raiders in Big 12 title contention.
Oregon's Dylan Raiola, a Nebraska transfer, threw for 336 yards and three touchdowns against No. 20 Northwestern after the Ducks fell behind 10-0. He completed 22-of-31 passes.
Oklahoma lost 42-25 to South Carolina at home. The Sooners allowed 28 points in the first half alone,